Miller B W, Howard T K, Goss J A, Mostello D J, Holcomb W L, Brennan D C
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Transplantation. 1995 Dec 15;60(11):1353-4.
A successful 38-week pregnancy is reported following renal transplantation approximately 1 week after conception. The patient was treated with quadruple sequential induction therapy, maintenance immunosuppression, and routine posttransplantation care, including ganciclovir treatment for a symptomatic cytomegalovirus infection during the pregnancy and 3 months after delivery. No decline in renal function was noted. The mother and child remain healthy at 18 months. This case demonstrates the ability of renal transplant patients to maintain renal function throughout pregnancy and the lack of deleterious effects upon the child during gestation and at up to 18 months after birth, despite significant immunosuppression, including antithymocyte globulin induction therapy, and infectious complications of the mother's renal transplantation.
据报道,一名患者在受孕后约1周接受肾移植,成功怀孕至38周。患者接受了四联序贯诱导治疗、维持免疫抑制治疗以及常规移植后护理,包括在孕期及产后3个月针对有症状的巨细胞病毒感染使用更昔洛韦治疗。未发现肾功能下降。母婴在18个月时均保持健康。该病例表明,肾移植患者在整个孕期能够维持肾功能,且尽管有显著的免疫抑制,包括抗胸腺细胞球蛋白诱导治疗以及母亲肾移植的感染并发症,但对胎儿在妊娠期及出生后长达18个月均无有害影响。