Gabrilovich D I, Vasilev V B, Nosikov V V, Serebrovskaia L V, Shepeleva G K, Ivanova L A, Pokrovskiĭ V V
Zh Mikrobiol Epidemiol Immunobiol. 1995 Sep-Oct(5):52-5.
Relationships between some clinical data and the detection of human immunodeficiency virus (HIV) DNA in polymorphonuclear neutrophils (PMN) of 37 HIV-infected persons were studied. HIV DNA was determined with the use of polymerase chain reaction. The level of HIV DNA in PMN, sufficient for determination, was mostly detected in persons with clinical manifestations of HIV infection and less frequently in asymptomatic patients (46.7% and 18.2% respectively, p < 0.05). The significant relationship between the presence of HIV DNA in NP and a decrease in the CD4/CD8 ratio, as well as an increase in the level of immunoglobulins in the blood serum, has been established. The presence of HIV DNA in PMN was positively related to the decrease of the functional activity of these cells and the level of PMN in peripheral blood. The infection of PMN with HIV may be one of important mechanisms of their damage in HIV infection.
研究了37名人类免疫缺陷病毒（HIV）感染者的一些临床数据与多形核中性粒细胞（PMN）中HIV DNA检测之间的关系。采用聚合酶链反应测定HIV DNA。PMN中足以进行测定的HIV DNA水平大多在有HIV感染临床表现的患者中检测到，而在无症状患者中较少见（分别为46.7%和18.2%，p<0.05）。已确定中性粒细胞中HIV DNA的存在与CD4/CD8比值降低以及血清免疫球蛋白水平升高之间存在显著关系。PMN中HIV DNA的存在与这些细胞功能活性的降低以及外周血中PMN水平呈正相关。PMN感染HIV可能是HIV感染中PMN损伤的重要机制之一。
