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In situ polymerase chain reaction detection of HTLV-I provirus and expression of the p53 tumor suppressor gene in infiltrating cells in skeletal muscle from a patient with adult T cell leukemia.

作者信息

Higuchi I, Hashimoto K, Kashio N, Izumo S, Matsuoka H, Nakagawa M, Osame M

机构信息

Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.

出版信息

Acta Neuropathol. 1995;90(3):323-7. doi: 10.1007/BF00296518.

DOI:10.1007/BF00296518
PMID:8525808
Abstract

We report the pathological changes in skeletal muscle from a patient with acute adult T cell leukemia (ATL). HTLV-I provirus was detected in infiltrating cells using in situ polymerase chain reaction in frozen sections. Furthermore, aberrant expression of the p53 protein was observed in the infiltrating cells. As p53 protein was not observed in mononuclear inflammatory cells in patients with polymyositis, expression of the p53 protein was considered to be one of the characteristic findings in ATL cells. This is the first direct detection of ATL cells in skeletal muscle.

摘要

相似文献

1
In situ polymerase chain reaction detection of HTLV-I provirus and expression of the p53 tumor suppressor gene in infiltrating cells in skeletal muscle from a patient with adult T cell leukemia.
Acta Neuropathol. 1995;90(3):323-7. doi: 10.1007/BF00296518.
2
Detection of HTLV-I provirus by in situ polymerase chain reaction in mononuclear inflammatory cells in skeletal muscle of viral carriers with polymyositis.通过原位聚合酶链反应检测多肌炎病毒携带者骨骼肌单核炎性细胞中的HTLV-I前病毒。
Muscle Nerve. 1995 Aug;18(8):854-8. doi: 10.1002/mus.880180809.
3
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本文引用的文献

1
Immunohistochemical characteristics of polymyositis in patients with HTLV-I-associated myelopathy and HTLV-I carriers.
Muscle Nerve. 1993 May;16(5):472-6. doi: 10.1002/mus.880160507.
2
Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells.p53肿瘤抑制基因在成人T细胞白血病和HTLV-I感染细胞中的异常表达。
Jpn J Cancer Res. 1993 Jan;84(1):4-8. doi: 10.1111/j.1349-7006.1993.tb02775.x.
3
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Differentiation between cutaneous form of adult T cell leukemia/lymphoma and cutaneous T cell lymphoma by in situ hybridization using a human T cell leukemia virus-1 DNA probe.使用人T细胞白血病病毒-1 DNA探针通过原位杂交鉴别成人T细胞白血病/淋巴瘤的皮肤型与皮肤T细胞淋巴瘤。
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Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS.在艾滋病潜伏期，人类免疫缺陷病毒对辅助性T淋巴细胞和巨噬细胞进行大量隐匿性感染。
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Blood. 1994 Aug 1;84(3):853-8.
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Skeletal muscle involvement in tropical spastic paraparesis/HTLV-1-associated myelopathy.热带痉挛性截瘫/人T细胞白血病病毒1型相关脊髓病中的骨骼肌受累情况
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Polymyositis in patients infected with human T-cell leukemia virus type I: the role of the virus in the cause of the disease.
Ann Neurol. 1994 Oct;36(4):643-9. doi: 10.1002/ana.410360414.
10
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.从一名皮肤T细胞淋巴瘤患者的新鲜淋巴细胞和培养淋巴细胞中检测并分离C型逆转录病毒颗粒。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9. doi: 10.1073/pnas.77.12.7415.