Brochard P, Bignon J
INSERM Unit 139, Hôpital Henri Mondor, Creteil, France.
Ann Occup Hyg. 1995 Oct;39(5):737-45. doi: 10.1016/0003-4878(95)00043-e.
The basis of a preventative health policy for humans against potential risks from chemical products is based on risk assessment leading to the classification and labeling of substances. However, the different existing classifications do not give an homogeneous framework that can be used in every country. Therefore, a tiered approach to assessing and classifying the health risk of exposure to fibres is proposed based on the EU Directive on carcinogens. The aim of this paper is to propose an algorithm for the risk assessment of existing and future fibres. Clearly chemically defined respirable fibres should be classified according to an algorithm based on a step-by-step procedure: a priori criteria, screening tests, long-term inhalation tests and epidemiological data (for commercial fibres). Then fibre-containing products should be labelled according to the classification of each type of fibre it contains, on one hand, and the ability of the product to release fibre in the air, on the other. The different tests listed in this algorithm, extensively discussed during the Workshop, are presented in detail in the following paper.
针对化学产品给人类带来的潜在风险制定预防性健康政策，其基础是基于风险评估对物质进行分类和标签标注。然而，现有的不同分类并未提供一个可在每个国家通用的统一框架。因此，基于欧盟关于致癌物的指令，提出了一种对纤维暴露健康风险进行评估和分类的分层方法。本文旨在提出一种针对现有和未来纤维进行风险评估的算法。明确化学定义的可吸入纤维应根据一种基于逐步程序的算法进行分类：先验标准、筛选测试、长期吸入测试以及流行病学数据（针对商业纤维）。然后，含纤维产品应一方面根据其所含每种纤维的分类，另一方面根据产品向空气中释放纤维的能力进行标签标注。本算法中列出的不同测试在研讨会上进行了广泛讨论，并在下文详细介绍。
