Helms J A, Della-Fera M A, Mott A E, Frank M E
Center for Neurological Sciences, University of Connecticut Health Center, Farmington, USA.
Arch Oral Biol. 1995 Oct;40(10):913-20. doi: 10.1016/0003-9969(95)00062-t.
Chlorhexidine gluconate at a dose used to control bacteria in the mouth has a reversible effect on taste perception. Taste-intensity ratings and taste-quality identification for concentration series of sucrose, sodium chloride, citric acid and quinine hydrochloride were obtained from 15 healthy humans. The participants rinsed with 0.12% chlorhexidine for 3 min twice a day. Each individual was tested 3 times: before the 4-day rinse period, 30 min after the final rinse, and 4 days after the rinse period. Chlorhexidine rinses reduced the perceptual intensity of sodium chloride and quinine hydrochloride, not sucrose or citric acid. No effects on taste perception were detected 4 days after the rinse period. The identification of sodium chloride as salty was seriously impaired by chlorhexidine but the identification of quinine hydrochloride as bitter was not affected. Specific sites of action of chlorhexidine on the taste epithelium are not known but its effects on salty taste may be related to its strong positive charge and its effect on bitter taste may be related to its amphiphilicity. Chlorhexidine has promise as a probe of taste transduction, as well as for the management of salty/bitter dysgeusias in humans.
用于控制口腔细菌的葡萄糖酸氯己定对味觉感知有可逆作用。从15名健康人身上获取了蔗糖、氯化钠、柠檬酸和盐酸奎宁浓度系列的味觉强度评分和味觉质量识别结果。参与者每天用0.12%的氯己定漱口两次，每次3分钟。每个人接受3次测试：在4天漱口期之前、最后一次漱口后30分钟以及漱口期结束后4天。氯己定漱口降低了氯化钠和盐酸奎宁的感知强度，但对蔗糖或柠檬酸没有影响。在漱口期结束4天后未检测到对味觉感知的影响。氯己定严重损害了将氯化钠识别为咸味的能力，但对将盐酸奎宁识别为苦味的能力没有影响。氯己定在味觉上皮细胞上的具体作用位点尚不清楚，但其对咸味的影响可能与其强正电荷有关，而其对苦味的影响可能与其两亲性有关。氯己定有望作为味觉转导的探针，以及用于治疗人类的咸/苦味觉障碍。
