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Stimulation of glyceraldehyde-3-phosphate dehydrogenase mRNA levels by endogenous nitric oxide in cytokine-activated endothelium.

作者信息

Bereta J, Bereta M

机构信息

Department of Biochemistry, Jagiellonian University, Cracow, Poland.

出版信息

Biochem Biophys Res Commun. 1995 Dec 5;217(1):363-9. doi: 10.1006/bbrc.1995.2785.

DOI:10.1006/bbrc.1995.2785
PMID:8526935
Abstract

Previous studies have shown that endogenous nitric oxide (NO) potentiates glycolysis in the cytokine-activated murine microvascular endothelial cells (MME). In the present study we investigate the influence of NO on the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an enzyme of the glycolytic pathway. Activation of MME with TNF-alpha and IFN-gamma resulted in a strong elevation of GAPDH mRNA levels. This effect was impaired in the presence of L-NMMA, the inhibitor of NO synthesis. We discuss the possibility that NO-mediated elevation of GAPDH mRNA levels may compensate for NO-mediated inhibition of GAPDH enzymatic activity, representing another adaptive mechanism which protects cells producing large amounts of NO against its cytotoxic effects.

摘要

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