Deville J G, Cherry J D, Christenson P D, Pineda E, Leach C T, Kuhls T L, Viker S
Department of Pediatrics, UCLA Medical Center, USA.
Clin Infect Dis. 1995 Sep;21(3):639-42. doi: 10.1093/clinids/21.3.639.
To investigate the frequency of unrecognized Bordetella pertussis infections in adults, we performed IgA and IgG ELISA antibody studies with four B. pertussis antigens--i.e., lymphocytosis-promoting factor, filamentous hemagglutinin, pertactin, and fimbriae-2--in 51 health care workers from whom six consecutive yearly serum samples (from 1984 to 1989) were available. Overall, 90% of the subjects had a significant increase in antibody (IgA or IgG) to one or more antigens between 2 consecutive years during the 5-year study period; 55% of subjects had evidence of two infections, 17% had three infections, and 4% had four infections. Infections occurred in all study years, with the following rates: 1984-1985, 32%; 1985-1986, 24%; 1986-1987, 40%; 1987-1988, 29%; and 1988-1989, 43% (P = .12). Some antibody rises may have been due to responses to cross-reacting antigens (Bordetella parapertussis, nontypable Haemophilus influenzae), but overall these data suggest that B. pertussis infections in adults are common, endemic, and usually unrecognized.
为了调查成人中未被识别的百日咳博德特氏菌感染的频率，我们对51名医护人员进行了IgA和IgG ELISA抗体研究，这些医护人员有连续6年（1984年至1989年）的血清样本。总体而言，在5年的研究期间，90%的受试者在连续两年中对一种或多种抗原的抗体（IgA或IgG）有显著增加；55%的受试者有两次感染的证据，17%有三次感染，4%有四次感染。所有研究年份均有感染发生，感染率如下：1984 - 1985年，32%；1985 - 1986年，24%；1986 - 1987年，40%；1987 - 1988年，29%；1988 - 1989年，43%（P = 0.12）。一些抗体升高可能是由于对交叉反应抗原（副百日咳博德特氏菌、不可分型流感嗜血杆菌）的反应，但总体而言，这些数据表明成人百日咳博德特氏菌感染很常见、呈地方性流行且通常未被识别。
