Panda A, Das G K, Khokhar S, Rao V
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Can J Ophthalmol. 1995 Aug;30(5):256-8.
To evaluate the efficacy of four antiviral agents--1% idoxuridine ointment (group 1), 2% trifluorothymidine ointment (group 2), 3% acyclovir ointment (group 3) and 1% bromovinyldeoxyuridine (BVDU) ointment (group 4)--in herpes simplex keratitis.
Randomized double-blinded clinical trial.
Tertiary care institution in New Delhi.
Eighty patients with uncomplicated herpes simplex keratitis of recent onset who had not previously received antiviral treatment.
Cure rate, frequency and severity of side effects.
Cure rates of 60%, 90%, 90% and 95% were obtained in groups 1, 2, 3 and 4 respectively. The average healing time was 13.4, 8.9, 8.5 and 7.5 days respectively. Side effects (follicular conjunctivitis, epithelial keratopathy and stinging) were more frequent in group 1 than in the other groups.
BVDU has a more pronounced therapeutic effect than idoxuridine, trifluorothymidine and acyclovir in uncomplicated epithelial herpetic disease of recent onset that has not previously been treated.
评估四种抗病毒药物——1%碘苷眼膏（第1组）、2%三氟胸腺嘧啶核苷眼膏（第2组）、3%阿昔洛韦眼膏（第3组）和1%溴乙烯脱氧尿苷（BVDU）眼膏（第4组）——治疗单纯疱疹性角膜炎的疗效。
随机双盲临床试验。
新德里的三级医疗机构。
80例近期发病的单纯疱疹性角膜炎患者，此前未接受过抗病毒治疗。
治愈率、副作用的发生率和严重程度。
第1、2、3和4组的治愈率分别为60%、90%、90%和95%。平均愈合时间分别为13.4、8.9、8.5和7.5天。第1组的副作用（滤泡性结膜炎、上皮性角膜病变和刺痛）比其他组更常见。
在近期发病且此前未接受治疗的单纯上皮性疱疹疾病中，BVDU比碘苷、三氟胸腺嘧啶核苷和阿昔洛韦具有更显著的治疗效果。
