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酵母减数分裂中源自人类的酵母人工染色体的形态学

Morphology of a human-derived YAC in yeast meiosis.

作者信息

Loidl J, Scherthan H, Den Dunnen J T, Klein F

机构信息

Institute of Botany, University of Vienna, Rennweg 14, A-1030 Vienna, Austria.

出版信息

Chromosoma. 1995 Nov;104(3):183-8. doi: 10.1007/BF00352183.

Abstract

In meiosis of human males DNA is packaged along pachytene chromosomes about 20 times more compactly than in meiosis of yeast. Nevertheless, a human-derived yeast artificial chromosome (YAC) shows the same degree of compaction of DNA as endogenous chromosomes in meiotic prophase nuclei of yeast. This suggests that in yeast meiosis, human and yeast DNA adopt a similar organization of chromatin along the pachytene chromosome cores. Therefore meiotic chromatin organization does not seem to be an inherent chromosomal property but is governed by the host-specific cellular environment. We suggest that there is a correlation between the less dense DNA packaging and the increased rate of recombination that has been reported for human-derived YACs as compared with human DNA in its natural environment.

摘要

在人类男性减数分裂过程中,DNA沿着粗线期染色体的包装紧密程度比酵母减数分裂时高出约20倍。然而,一种源自人类的酵母人工染色体(YAC)在酵母减数分裂前期细胞核中,其DNA的压缩程度与内源性染色体相同。这表明在酵母减数分裂中,人类和酵母的DNA在粗线期染色体核心周围采用了相似的染色质组织形式。因此,减数分裂染色质组织似乎并非染色体的固有属性,而是由宿主特异性细胞环境所决定。我们认为,与自然环境中的人类DNA相比,人类源YACs报道的较低密度DNA包装与较高的重组率之间存在相关性。

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