Buser D, Ruskin J, Higginbottom F, Hardwick R, Dahlin C, Schenk R K
Department of Oral Surgery, School of Dental Medicine, University of Berne, Switzerland.
Int J Oral Maxillofac Implants. 1995 Nov-Dec;10(6):666-81.
In the present histologic study of the mandibles of five foxhounds, 15 nonsubmerged titanium implants were placed in bone regenerated in extended membrane-protected defects during a 6-month healing period. The clinical and radiographic evaluation demonstrated that all 15 implants achieved functional ankylosis within 3 months following implant placement. Subsequently, eight implants were restored with fixed partial dentures and were functionally loaded for 6 months, and seven implants were left unrestored. At the completion of the study, the histologic analysis demonstrated osseointegration with direct bone-to-implant contact for all 15 implants. Therefore, it can be concluded that bone regenerated in membrane-protected defects responds to implant placement like nonregenerated bone, and that this bone is capable of bearing and sustaining functional load. The histologic comparison of restored and unrestored sites demonstrated no apparent differences concerning bone remodeling activities. Furthermore, control sites without implant placement demonstrated bone atrophy underneath the membranes with a thin cortical layer and sparse bone trabeculae. Thus, it can also be concluded that the placement of an implant into regenerated bone stimulated bone maturation and bone remodeling, whereas implant loading did not influence bone remodeling in the present study model.
在对五只猎狐犬下颌骨的当前组织学研究中，在为期6个月的愈合期内，将15颗非埋入式钛种植体植入在扩展膜保护缺损处再生的骨中。临床和影像学评估表明，所有15颗种植体在植入后3个月内均实现了功能性骨结合。随后，8颗种植体用固定局部义齿修复并进行了6个月的功能加载，7颗种植体未进行修复。在研究结束时，组织学分析表明所有15颗种植体均实现了骨整合，骨与种植体直接接触。因此，可以得出结论，在膜保护缺损处再生的骨对种植体植入的反应与未再生的骨相似，并且这种骨能够承受和维持功能负荷。修复部位和未修复部位的组织学比较表明，在骨重塑活动方面没有明显差异。此外，未植入种植体的对照部位在膜下方显示出骨萎缩，皮质层薄且骨小梁稀疏。因此，还可以得出结论，在本研究模型中，将种植体植入再生骨中可刺激骨成熟和骨重塑，而种植体加载并未影响骨重塑。
