Sjaastad O, Antonaci F
Department of Neurology, Trondheim, Norway, University Hospitals.
Headache. 1995 Oct;35(9):549-50. doi: 10.1111/j.1526-4610.1995.hed3509549.x.
Piroxicam beta-cyclodextrin has recently been observed to be equal to, or even possibly to be superior to, indomethacin (mainly with regard to side effects) in a single case of hemicrania continue. Piroxicam beta-cyclodextrin, 20 to 40 mg per day, was, accordingly, tried in six patients with chronic paroxysmal hemicrania and six patients with hemicrania continua with a previously proven response to indomethacin. The study was conducted over a period of 3 weeks and in an open fashion. A placebo effect is considered to be negligible in these disorders. In such a comparison, piroxicam beta-cyclodextrin seemed inferior to indomethacin, in particular in chronic paroxysmal hemicrania.
在1例持续性偏侧头痛患者中，最近观察到吡罗昔康β-环糊精在疗效上等同于甚至可能优于吲哚美辛（主要在副作用方面）。因此，对6例慢性发作性偏侧头痛患者和6例对吲哚美辛有明确反应的持续性偏侧头痛患者试用了每日20至40毫克的吡罗昔康β-环糊精。该研究为期3周，采用开放方式进行。在这些疾病中，安慰剂效应被认为可忽略不计。在这样的比较中，吡罗昔康β-环糊精似乎不如吲哚美辛，尤其是在慢性发作性偏侧头痛中。
