关于甲基丙烯酸甲酯在血液中的转归
On the fate of methyl methacrylate in blood.
作者信息
Rijke A M, Johnson R A, Oser E R
出版信息
J Biomed Mater Res. 1977 Mar;11(2):211-21. doi: 10.1002/jbm.820110207.
The fate of methyl methacrylate in fresh human blood was investigated in vitro by using gas chromatography. It was found that methyl methacrylate is present in cells in concentrations twice as large as in plasma, but it disappears exponentially with time at a rate that is at least 10 times faster than that in cells. The rate constant in cells is very small or even zero. The half-life of methyl methacrylate in whole blood is 3 hr at 20 degrees C. Gas chromatography is a convenient method for the rapid determination of methyl methacrylate levels in blood.
采用气相色谱法在体外研究了甲基丙烯酸甲酯在新鲜人血中的代谢情况。结果发现，甲基丙烯酸甲酯在细胞中的浓度是血浆中的两倍，但随着时间的推移呈指数下降，其下降速率至少比在细胞中的快10倍。细胞中的速率常数非常小甚至为零。在20℃时，甲基丙烯酸甲酯在全血中的半衰期为3小时。气相色谱法是快速测定血液中甲基丙烯酸甲酯含量的便捷方法。
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