Kohn C W, Swardson C, Provost P, Gilbert R O, Couto C G
Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210, USA.
J Vet Intern Med. 1995 Sep-Oct;9(5):315-23. doi: 10.1111/j.1939-1676.1995.tb01090.x.
Myeloid and megakaryocytic bone marrow hypoplasia in association with moderate to profound neutropenia was observed in 8 young Standardbred horses sired by the same stallion; 7 horses were intermittently thrombocytopenic. Evaluation of serial neutrophil counts in 2 horses suggested that a cyclic variation in neutrophil numbers was present, that lymphocyte numbers increased when neutrophil counts decreased, and that platelet counts decreased when neutrophil counts decreased. Preliminary bone marrow cultures indicated that myeloid progenitor cells were present and that these cells were able to respond to exogenous growth factors by differentiating. A bone marrow microenvironment or growth factor defect is suspected. Seven of 8 horses died or were euthanized. One horse with moderate neutropenia and a normal platelet count has been racing for 3 years. Necropsies in 4 horses did not reveal a cause for the myeloid hypoplasia. A familial basis for the disease is suspected.
在8匹由同一匹种马所生的年轻标准赛马中，观察到骨髓中髓细胞和巨核细胞发育不全，并伴有中度至重度中性粒细胞减少；7匹马间歇性血小板减少。对2匹马的系列中性粒细胞计数评估表明，中性粒细胞数量存在周期性变化，中性粒细胞计数减少时淋巴细胞数量增加，中性粒细胞计数减少时血小板计数减少。初步骨髓培养表明存在髓系祖细胞，并且这些细胞能够通过分化对外源生长因子作出反应。怀疑存在骨髓微环境或生长因子缺陷。8匹马中有7匹死亡或被安乐死。1匹患有中度中性粒细胞减少且血小板计数正常的马已经参加比赛3年了。对4匹马进行尸检未发现髓细胞发育不全的原因。怀疑该病有家族性基础。
