Sellon D C, Levine J, Millikin E, Palmer K, Grindem C, Covington P
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
J Vet Intern Med. 1996 May-Jun;10(3):127-32. doi: 10.1111/j.1939-1676.1996.tb02044.x.
The records of 3,952 equine patients presenting to the Veterinary Teaching Hospital at North Carolina State University College of Veterinary Medicine were evaluated to determine risk factors associated with thrombocytopenia. Of 2,346 horses from which a CBC was obtained, 35 (1.49%) were thrombocytopenic (platelet count < 75,000/microL). A reference population of 189 horses with normal platelet counts (75,000 to 300,000/microL) was also studied. Standardbred horses were at increased risk for thrombocytopenia, but age and gender were not identified as significant risk factors. Horses with infectious or inflammatory diseases were at increased risk for thrombocytopenia. The potential association of clinical and clinicopathologic factors with thrombocytopenia were assessed by reviewing a series of multiple logistic regression models. Clinical and clinicopathologic variables significantly associated with thrombocytopenia in the final model included increased PCV, increased band neutrophil count, increased total WBC, and decreased plasma protein concentration. Increased mature neutrophil count was associated with normal platelet counts. Thrombocytopenic horses were significantly more likely to die to be euthanized than were horses with normal platelet counts.
对北卡罗来纳州立大学兽医学院兽医教学医院收治的3952例马科动物患者的记录进行了评估，以确定与血小板减少症相关的风险因素。在获得全血细胞计数（CBC）的2346匹马中，35匹（1.49%）出现血小板减少（血小板计数<75,000/微升）。还对189匹血小板计数正常（75,000至300,000/微升）的马匹作为参考群体进行了研究。标准赛马患血小板减少症的风险增加，但年龄和性别未被确定为显著风险因素。患有感染性或炎症性疾病的马匹患血小板减少症的风险增加。通过回顾一系列多元逻辑回归模型，评估了临床和临床病理因素与血小板减少症之间的潜在关联。最终模型中与血小板减少症显著相关的临床和临床病理变量包括红细胞压积增加、杆状核中性粒细胞计数增加、白细胞总数增加和血浆蛋白浓度降低。成熟中性粒细胞计数增加与血小板计数正常相关。与血小板计数正常的马匹相比，血小板减少的马匹死亡或被安乐死的可能性显著更高。
