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[精神分裂症患者红细胞膜、血小板和α-脂蛋白中磷脂的脂肪酸组成]

[The fatty acid composition of the phospholipids of the erythrocyte membranes, thrombocytes and alpha-lipoproteins in schizophrenia patients].

作者信息

Iusupova I U

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1995;95(4):58-62.

PMID:8533512
Abstract

19 patients with different forms of schizophrenia as well as 10 healthy individuals and 6 alcoholic patients as a controls were examined. In was found that the fatty acid composition of phospholipids from schizophrenic patients erythrocytes membranes and platelets was not differed from control groups except the continuous sluggish schizophrenic patients. The decrease of polyunsaturated fatty acids C 20:3 (w = 9) and the increase C 20:5 (w = 6) were observed in the last case. The decrease of linoleic acid and C 20:5 (w = 3) acids levels in phospholipids of alpha-lipoprotein fraction was observed in all patients independently of their nosological form. The author suggests that last finding is the possible cause of the fatty acids deficiency chronization in brain structures.

摘要

对19例不同类型精神分裂症患者、10名健康个体以及6名酒精性患者作为对照进行了检查。发现除持续迟钝型精神分裂症患者外,精神分裂症患者红细胞膜和血小板中磷脂的脂肪酸组成与对照组无差异。在后一种情况下,观察到多不饱和脂肪酸C 20:3(ω=9)减少,C 20:5(ω=6)增加。在所有患者中,无论其疾病类型如何,均观察到α-脂蛋白部分磷脂中亚油酸和C 20:5(ω=3)酸水平降低。作者认为,最后这一发现可能是脑结构中脂肪酸缺乏慢性化的原因。

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