真菌中果糖基氨基酸氧化酶的分布与特性
Distribution and properties of fructosyl amino acid oxidase in fungi.
作者信息
Yoshida N, Sakai Y, Serata M, Tani Y, Kato N
机构信息
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan.
出版信息
Appl Environ Microbiol. 1995 Dec;61(12):4487-9. doi: 10.1128/aem.61.12.4487-4489.1995.
Abstract
Fructosyl amino acid oxidase, and enzyme that can be used for the determination of glycated proteins in blood samples from diabetic patients, was used to screen cultures in our microorganism culture collection. Fructosyl amino acid oxidase was found only in the strains of four genera of fungi, Aspergillus, Fusarium, Gibberella, and Penicillium and exhibited different substrate specificities against fructosyl valine and N epsilon-fructosyl N alpha-Z-lysine. A fructosyl valine-specific enzyme from Penicillium janthinellum AKU3413 was monomeric (M(r), 49,000), was most active at 35 degrees C and pH 8.0, and had a covalently bound flavin adenine dinucleotide as a prosthetic group.
摘要
果糖基氨基酸氧化酶是一种可用于测定糖尿病患者血样中糖化蛋白的酶，我们用它来筛选微生物培养物保藏中心的培养物。结果发现，果糖基氨基酸氧化酶仅存在于曲霉属、镰刀菌属、赤霉菌属和青霉属这四个真菌属的菌株中，并且对果糖基缬氨酸和Nε-果糖基-Nα-Z-赖氨酸表现出不同的底物特异性。来自淡紫青霉AKU3413的一种果糖基缬氨酸特异性酶是单体（相对分子质量为49,000），在35℃和pH 8.0时活性最高，并且含有共价结合的黄素腺嘌呤二核苷酸作为辅基。
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