Karpov A V, Zholobak N M
Antibiot Khimioter. 1995 May;40(5):20-3.
The use of molecular complexes of yeast RNA with thyloron as inductors of type I interferons (alpha/beta-interferons) in the culture of cells L929 is described. It was shown that the complexes induced the interferon synthesis in the cells at the level comparable to that of the standard inductors of the polyribonucleotide nature i.e. larifan and poly(I)-poly(C). In the experimental doses the complexes proved to be nontoxic. It was concluded that the use of the yeast RNA and thyloron complexes as inductors in large-scale production of type I interferons was promising.
描述了在L929细胞培养中使用酵母RNA与噻罗隆的分子复合物作为I型干扰素（α/β干扰素）诱导剂的情况。结果表明，这些复合物在细胞中诱导干扰素合成的水平与多聚核苷酸性质的标准诱导剂（即拉立泛和聚肌苷酸-聚胞苷酸）相当。在实验剂量下，这些复合物被证明无毒。得出的结论是，在大规模生产I型干扰素中使用酵母RNA和噻罗隆复合物作为诱导剂是有前景的。
