Schaller A, Bergey D R, Ryan C A
Institute of Biological Chemistry, Washington State University, Pullman 99164-6340, USA.
Plant Cell. 1995 Nov;7(11):1893-8. doi: 10.1105/tpc.7.11.1893.
Bestatin, an inhibitor of some aminopeptidases in plants and animals, is a powerful inducer of defense genes in tomato leaves; these genes are also induced by herbivore attacks, mechanical wounding, systemin, and methyl jasmonate. Unlike wounding and systemin, bestatin does not cause an increase in intracellular jasmonic acid concentrations, and inhibitors of the octadecanoid pathway do not inhibit induction by bestatin. Furthermore, defense genes were induced by bestatin in a mutant tomato line (JL-5) with a defect in the octadecanoid pathway. Bestatin therefore appears to be exerting its effects close to the level of transcriptional control of these genes, where it may be inhibiting a regulatory protease.
抑氨肽酶素是动植物中某些氨肽酶的抑制剂，是番茄叶片中防御基因的强效诱导剂；这些基因也可由食草动物攻击、机械损伤、系统素和茉莉酸甲酯诱导。与损伤和系统素不同，抑氨肽酶素不会导致细胞内茉莉酸浓度升高，并且十八烷途径的抑制剂不会抑制抑氨肽酶素的诱导作用。此外，在十八烷途径存在缺陷的突变番茄品系（JL-5）中，抑氨肽酶素也能诱导防御基因。因此，抑氨肽酶素似乎在这些基因转录控制水平附近发挥作用，在这个水平它可能抑制一种调节性蛋白酶。
