Ferrara F, Cancemi D, Friso P, Gaglione M, Picardi A, Rossi L, Scognamiglio M
Division of Hematology, Cardarelli Hospital, Naples, Italy.
Leuk Lymphoma. 1996 Feb;20(5-6):513-5. doi: 10.3109/10428199609052439.
We report a case of tetrasomy 8 in a patient suffering from acute myelomonocytic leukemia with extensive leukemic cutaneous infiltration. In all metaphases analyzed t( I;11)(p32;q24) was concomitantly observed. Similarly to other cases with tetrasomy 8, the patient showed monocytic involvement and poor response to chemotherapy. We conclude that this kind of cytogenetic aberration is associated with distinct morphologic and clinical features.
我们报告了一例患有急性粒单核细胞白血病并伴有广泛白血病皮肤浸润的患者出现8号染色体四体的病例。在所有分析的中期相中，均同时观察到t(1;11)(p32;q24)。与其他8号染色体四体的病例相似，该患者表现为单核细胞受累且对化疗反应不佳。我们得出结论，这种细胞遗传学异常与独特的形态学和临床特征相关。
