普列克底物蛋白同源结构域与志贺毒素之间的结构相似性：结构相似性的测量与评估问题
Structural similarity between the pleckstrin homology domain and verotoxin: the problem of measuring and evaluating structural similarity.
作者信息
Orengo C A, Swindells M B, Michie A D, Zvelebil M J, Driscoll P C, Waterfield M D, Thornton J M
机构信息
Department of Biochemistry and Molecular Biology, University College, London, United Kingdom.
出版信息
Protein Sci. 1995 Oct;4(10):1977-83. doi: 10.1002/pro.5560041003.
Abstract
An unexpected structural similarity is described between the pleckstrin homology (PH) domain and verotoxin. This similarity has escaped detection primarily due to the differences in topology that exist between the two proteins. By comparing this result with two previously reported similarities for the PH domain, one with the lipocalins and another with the FK506 binding protein, we discuss the problems of measuring and assessing structural similarities.
摘要
本文描述了普列克底物蛋白同源（PH）结构域与维罗毒素之间意外的结构相似性。这种相似性此前未被发现，主要是由于这两种蛋白质在拓扑结构上存在差异。通过将这一结果与之前报道的PH结构域的另外两种相似性（一种是与脂质运载蛋白的相似性，另一种是与FK506结合蛋白的相似性）进行比较，我们讨论了测量和评估结构相似性的问题。
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