Maat B
J Natl Cancer Inst. 1977 May;58(5):1433-6. doi: 10.1093/jnci/58.5.1433.
In view of clinical data supporting a casual relationship between long-term L-dopa administration and recurrence of melanoma, long-term L-dopa administration to aged rats was performed to investigate its effect on the incidence of malignant melanoma. Of the treated animals, 11% showed local pigmented epidermal hyperplasia, compared with 0.5% of the control animals, but the number of expected melanomas was not increased by L-dopa treatment.
鉴于临床数据支持长期服用左旋多巴与黑色素瘤复发之间存在因果关系，我们对老年大鼠进行了长期左旋多巴给药，以研究其对恶性黑色素瘤发病率的影响。在接受治疗的动物中，11%出现局部色素沉着性表皮增生，而对照动物为0.5%，但左旋多巴治疗并未增加预期的黑色素瘤数量。
