Järup L, Carlsson M D, Elinder C G, Hellström L, Persson B, Schütz A
Department of Environmental Health and Infectious Diseases Control, Karolinska Hospital, Stockholm, Sweden.
Occup Environ Med. 1995 Nov;52(11):770-2. doi: 10.1136/oem.52.11.770.
To study the body burden of cadmium and signs of tubular dysfunction in a rural population living near a closed nickel cadmium battery plant.
Cadmium and N-acetyl-beta-glucosaminidase (NAG) in urine were measured in 72 subjects who lived close to the plant.
Residents living close to the plant had higher median urinary cadmium concentrations than those living farther away (1.01 v 0.46 nmol/mmol creatinine) and than a control group (0.2 nmol/mmol creatinine). There was a significant correlation between urinary cadmium and the excretion of NAG in urine as well as signs of tubular dysfunction in residents who excreted urinary cadmium above 0.5 nmol/mmol creatinine.
Tubular dysfunction may appear in environmentally exposed subjects at lower cadmium body burdens than previously anticipated.
研究居住在一家已关闭的镍镉电池厂附近的农村人口体内镉的负荷及肾小管功能障碍迹象。
对72名居住在该厂附近的受试者进行尿镉和N - 乙酰 - β - 氨基葡萄糖苷酶（NAG）检测。
居住在该厂附近的居民尿镉浓度中位数高于居住在较远地区的居民（分别为1.01对0.46纳摩尔/毫摩尔肌酐）以及对照组（0.2纳摩尔/毫摩尔肌酐）。在尿镉排泄量高于0.5纳摩尔/毫摩尔肌酐的居民中，尿镉与尿中NAG排泄量以及肾小管功能障碍迹象之间存在显著相关性。
与之前预期相比，在环境暴露人群中，较低的镉体内负荷可能就会出现肾小管功能障碍。
