Tang-Liu D, Lambert J, Blancaflor S, Gwon A
Department of Pharmacokinetics, Allergan, Inc., Irvine, California, USA.
J Ocul Pharmacol Ther. 1995 Spring;11(1):57-63. doi: 10.1089/jop.1995.11.57.
Ofloxacin 0.3% ophthalmic solution or ointment was administered preoperatively to 13 patients undergoing cataract surgery. Mean drug concentrations in conjunctival biopsies were 2.62 and 6.55 micrograms/gm and in aqueous humor samples were 0.36 micrograms/mL and 0.43 micrograms/mL, for ointment and solution respectively. Mean conjunctival concentrations of ofloxacin achieved MIC90 values for 419 gram-positive and gram-negative organisms previously analyzed.
对13例接受白内障手术的患者术前给予0.3%氧氟沙星眼药水或眼膏。结膜活检组织中的平均药物浓度，眼膏组和眼药水组分别为2.62和6.55微克/克，房水样本中的平均药物浓度分别为0.36微克/毫升和0.43微克/毫升。氧氟沙星在结膜中的平均浓度对先前分析的419种革兰氏阳性和革兰氏阴性菌达到了MIC90值。
