Salgado A V, Ferro J M
Serviço de Neurologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Portugal.
Cephalalgia. 1995 Oct;15(5):410-3. doi: 10.1046/j.1468-2982.1995.1505410.x.
The presence of headache within a 72-h interval of stroke onset was investigated in a cohort of 145 lacunar infarcts. Fourteen (10%) experienced diffuse or bilateral headache. Hypertension was less frequent (43 vs 76%; 95% CI: 6 to 60%) and of shorter duration (2.4 vs 7.8 years; t = 2.29; p = 0.02) among patients with headache. Leukoaraiosis was less frequent (40% vs 71%; 95% CI: -57 to -7%) and severe (7 vs 24%; 95% CI: -33 to -2%) in patients with headache. Age, sex, stroke risk factors, type of lacunar stroke, mode of onset, stroke severity, ultrasound and other CT findings were similar in patients with and without headache. No differences in the sixth month neurological or functional outcome were detected between lacunar patients with and without headache. Headache in lacunar stroke cannot be predicted by the clinical characteristics of the stroke and is not due to coexisting cardiembolism, intra or extracranial disease. Hypertensive small-vessel disease is less common and severe in lacunar strokes with associated headache.
在一个包含145例腔隙性梗死患者的队列中，对卒中发作72小时内头痛的出现情况进行了调查。14例（10%）经历了弥漫性或双侧性头痛。头痛患者中高血压的发生率较低（43%对76%；95%置信区间：6%至60%），且病程较短（2.4年对7.8年；t = 2.29；p = 0.02）。头痛患者中白质疏松症的发生率较低（40%对71%；95%置信区间：-57%至-7%），且严重程度较低（7%对24%；95%置信区间：-33%至-2%）。有头痛和无头痛的患者在年龄、性别、卒中危险因素、腔隙性卒中类型、发病方式、卒中严重程度、超声及其他CT表现方面相似。有头痛和无头痛的腔隙性梗死患者在第六个月的神经功能或功能结局方面未发现差异。腔隙性卒中的头痛不能通过卒中的临床特征预测，也不是由于并存的心源性栓塞、颅内或颅外疾病所致。伴有头痛的腔隙性卒中中高血压性小血管疾病较少见且病情较轻。
