Whitehead T P, Robinson D, Allaway S L, Hale A C
BUPA Medical Research, London, UK.
Clin Lab Haematol. 1995 Jun;17(2):131-8.
The objective of this study was to quantify the combined dose related effects of cigarette smoking and alcohol consumption on blood haemoglobin concentration, erythrocytes and leucocytes. The subjects consisted of 17,670 males attending for routine health screening, with an average age of 43 years and a range of 16-91 years. The number of cigarettes smoked each day was divided into six categories, and declared alcohol consumption into seven. Of the 42 different combinations of smoking and drinking groups, five were not reported because they contained less than 30 subjects. Haemoglobin concentration was significantly increased in those smoking more than 10 cigarettes per day. Smoking also increased the PCV. Alcohol had no effect on Hb or PCV. The red cell count was reduced by alcohol consumption, with even the lowest consumption producing a significant decrease. Both smoking and drinking raised the MCV in a linear dose relationship. The marked increase in white cell count with smoking was seen even in subjects smoking 10 cigarettes per day or less. It is suggested that social habits such as smoking and drinking should be considered when interpreting blood haematology values. Changes in haematology results could be used to encourage a healthier lifestyle.
本研究的目的是量化吸烟和饮酒对血液血红蛋白浓度、红细胞和白细胞的联合剂量相关影响。研究对象包括17670名接受常规健康筛查的男性，平均年龄43岁，年龄范围为16 - 91岁。每天吸烟的数量分为六类，报告的饮酒量分为七类。在吸烟和饮酒组的42种不同组合中，有五种未报告，因为其受试者少于30人。每天吸烟超过10支者的血红蛋白浓度显著升高。吸烟还会使红细胞压积升高。饮酒对血红蛋白或红细胞压积没有影响。饮酒会使红细胞计数减少，即使饮酒量最低也会导致显著下降。吸烟和饮酒均以线性剂量关系使平均红细胞体积升高。即使在每天吸烟10支或更少的受试者中，也观察到吸烟会使白细胞计数显著增加。建议在解释血液血液学值时应考虑吸烟和饮酒等社会习惯。血液学结果的变化可用于鼓励更健康的生活方式。
