Junaid M, Murthy R C, Saxena D K
Embryotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Vet Hum Toxicol. 1995 Aug;37(4):320-3.
Female mice received 250, 500 or 750 ppm chromium (VI) as potassium dichromate in drinking water on days 14 to 19 of pregnancy. Gestational weight gain of mothers, fetal weight and crown-rump length decreased in the 500 and 750 ppm groups. The high-dose group also had significantly higher incidences of postimplantation loss. Significant increases in drooping wrists, subdermal hemorrhagic patches, kinky and short tails, and reduced ossification were also found in the 750 ppm group. Chromium levels were increased in a dose-dependent manner in maternal blood and placenta and in fetuses. Our study suggests a risk to the developing fetus if the mother is exposed to high concentrations of chromium (VI) during pregnancy.
在妊娠第14至19天，雌性小鼠通过饮用含250、500或750 ppm六价铬（以重铬酸钾形式）的水来接触该物质。500 ppm和750 ppm组的母鼠孕期体重增加、胎儿体重和顶臀长度均下降。高剂量组的着床后损失发生率也显著更高。在750 ppm组中还发现腕部下垂、皮下出血斑、尾巴卷曲短小以及骨化减少的情况显著增加。母血、胎盘和胎儿中的铬水平呈剂量依赖性增加。我们的研究表明，如果母亲在孕期接触高浓度的六价铬，对发育中的胎儿存在风险。
