Kanojia R K, Junaid M, Murthy R C
Metal Analysis Laboratory, Industrial Toxicology Research Centre, M. G. Marg, Lucknow, India.
Toxicol Lett. 1996 Dec 31;89(3):207-13. doi: 10.1016/s0378-4274(96)03812-x.
Exposure to chromium (VI) (250, 500 and 750 ppm as potassium dichromate) via drinking water pregestationally in rats revealed embryo- and fetotoxic effects in the form of a significant reduction in the number of implantations and number of fetuses. An increase in the number of resorptions, pre-implantation and post-implantation loss in chromium (VI)-treated mothers was also observed. No significant visceral abnormality was found. A significant increase in sub-dermal hemorrhagic patches on thoracic and abdominal areas was found. Skeletal abnormality in the form of reduced ossification in parietal, interparietal and caudal bones was found in the fetuses of chromium (VI)-treated mothers. Chromium levels in blood, placenta and fetuses were found to be significantly increased in the 500 ppm and 750 ppm dosed groups. The duration of estrus cycle was significantly altered after chromium (VI) exposure. This study suggests that chromium exposure in rat causes a lower degree of toxicity than in mice as observed in our earlier studies.
在大鼠孕期通过饮用水给予六价铬（以重铬酸钾计，浓度分别为250、500和750 ppm），结果显示出胚胎毒性和胎儿毒性效应，表现为着床数量和胎儿数量显著减少。在接受六价铬处理的母鼠中，还观察到吸收数量、着床前和着床后损失增加。未发现明显的内脏异常。发现胸腹部皮下出血斑显著增加。在接受六价铬处理的母鼠所产胎儿中，发现顶骨、顶间骨和尾骨骨化程度降低形式的骨骼异常。在500 ppm和750 ppm剂量组中，血液、胎盘和胎儿中的铬水平显著升高。六价铬暴露后，发情周期时长发生显著改变。本研究表明，与我们早期研究中观察到的小鼠相比，大鼠接触铬所导致的毒性程度较低。
