Junaid M, Murthy R C, Saxena D K
Embryotoxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Toxicol Lett. 1996 Mar;84(3):143-8. doi: 10.1016/0378-4274(95)03607-5.
Administration of chromium (VI)(250, 500 and 750 ppm as potassium dichromate) via drinking water during organogenesis (days 6-14 of gestation) in mice revealed embryo- and fetotoxic effects. Reduced fetal weight, retarded fetal development, number of fetuses (live and dead) per mother and high incidences of dead fetuses and resorptions in treated mothers in the highest dosed group were evident. No significant gross structural abnormalities were observed in any of the fetuses of chromium (VI)-treated mothers. Significant incidences of reduced ossification were found in the highest dosed group. Chromium levels were increased in a dose-dependent manner in maternal blood, placenta and fetuses. The present study suggests a risk to the developing embryo if the mother is exposed to a sufficiently high concentration of chromium (VI) through drinking water during the period of organogenesis.
在小鼠器官形成期（妊娠第6 - 14天），通过饮用水给予六价铬（以重铬酸钾计，浓度为250、500和750 ppm），结果显示出胚胎毒性和胎儿毒性作用。在最高剂量组中，明显可见胎儿体重减轻、胎儿发育迟缓、每只母鼠的胎儿数量（存活和死亡）减少，以及处理组母鼠中死胎和吸收胎的发生率较高。在六价铬处理母鼠的任何胎儿中均未观察到明显的大体结构异常。在最高剂量组中发现骨化减少的发生率显著增加。母血、胎盘和胎儿中的铬水平呈剂量依赖性增加。本研究表明，如果母亲在器官形成期通过饮用水接触到足够高浓度的六价铬，对发育中的胚胎存在风险。
