Jackson M H, Payne H A
Macfarlan Smith Ltd., Edinburgh, Scotland, United Kingdom.
Vet Hum Toxicol. 1995 Aug;37(4):323-6.
Ethylene glycol automobile engine coolants and methanol-based windshield washer liquids are toxic. Despite international attempts to improve the safety of these products through better labelling and packaging, accidental and intentional ingestions continue a source of poisonings worldwide. The rejection of bitter tasting substances forms part of the human defense against ingestion of harmful substances. Denatonium benzoate (DB) is currently recognised as a means to prevent ingestion of ethyl alcohol intended for industrial use. This study investigated the use of this bitter substance also as a deterrent against ingesting ethylene glycol and methanol. The palatability of ethylene glycol and methanol with and without the addition of DB was assessed using a human taste panel; 30 ppm DB rendered each product intolerable to the panel. The addition of DB to ethylene glycol engine coolants and methanol-based windshield washer liquids at low concentrations could afford protection against accidental ingestions.
乙二醇汽车发动机冷却液和甲醇基挡风玻璃清洗液有毒。尽管国际上试图通过更好的标签和包装来提高这些产品的安全性，但意外和故意摄入仍是全球中毒的一个来源。对苦味物质的排斥是人类抵御有害物质摄入的一部分。苯甲地那铵（DB）目前被认为是防止摄入工业用乙醇的一种手段。本研究调查了这种苦味物质作为一种威慑剂来防止摄入乙二醇和甲醇的用途。使用人类味觉小组评估了添加和不添加DB的乙二醇和甲醇的适口性；30 ppm的DB使每种产品对该小组来说都难以忍受。在乙二醇发动机冷却液和甲醇基挡风玻璃清洗液中低浓度添加DB可以提供防止意外摄入的保护。
