Hüttig G, Gekle D
Monatsschr Kinderheilkd (1902). 1977 Apr;125(4):185-9.
76 children with glomerulonephritis (biopsy diagnosed) were studied for evidence of preceeding streptococcal infection, morphological and clinical symptoms. Glomerulonephritis often shows minimal symptoms; only 11% had acute, but 80% subclinical symptoms. Heading symptom was hematuria (95%), in 55% there was additional proteinuria. No correlation could be found between the clinical symptoms and glomerular lesions. Antistreptolysin 0 titers were elevated in only 39% of the children, but in all with acute clinical symptoms. The aetiology of glomerulonephritis in the remainder is uncertain, probably virus infections. The reason for decreased nephritis and increased subclinical nephritis is due to penicillin therapy and the improved renal diagnosis (renal biopsy).
对76名经活检确诊为肾小球肾炎的儿童进行了研究，以寻找先前链球菌感染的证据、形态学和临床症状。肾小球肾炎通常症状轻微；只有11%的患儿有急性症状，但80%有亚临床症状。主要症状是血尿（95%），55%的患儿伴有蛋白尿。临床症状与肾小球病变之间未发现相关性。仅39%的患儿抗链球菌溶血素O滴度升高，但所有有急性临床症状的患儿抗链球菌溶血素O滴度均升高。其余患儿肾小球肾炎的病因尚不确定，可能是病毒感染。肾炎减少和亚临床肾炎增加的原因是青霉素治疗和肾脏诊断（肾活检）的改善。
