Changchien C S, Chuah S K, Chiu K W
Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan, R.O.C.
Am J Gastroenterol. 1995 Dec;90(12):2124-7.
Laparoscopic cholecystectomy (LC) has become the choice of treatment for symptomatic gallbladder stones. The goal of this study was to predict the necessity for ERCP before LC using the noninvasive method of liver function testing (LFT) and sonography.
Before LC, 115 symptomatic gallbladder stone patients, whose diagnoses were confirmed by sonography, were studied by both LFT and ERCP. Patients who were already found to have either tumors or intrahepatic biliary stones on sonogram were excluded. Patients were classified into normal and dilated biliary tree groups by sonographic findings and normal and abnormal LFT (including bilirubin, alkaline phosphatase, gamma glutamyl transferase and amylase) groups.
In patients with both normal biliary sonogram and LFT, 97.6% of patients had a negative ERCP study. Biliary tree dilation on sonogram had an 87% positive predictability for ductal pathology on ERCP (40/46). A normal biliary tree on sonogram had a 17.4% incidence of positive ductal pathology on ERCP (12/69). A single abnormal LFT equated to a 68.8% positive predictability for ductal pathology on ERCP.
ERCP is not necessary before LC for patients with symptomatic gallbladder stones who have both a normal biliary tree on sonogram and normal LFT. A patient with either a dilated bile duct on sonogram or an abnormal liver function test does require ERCP study.
腹腔镜胆囊切除术(LC)已成为有症状胆囊结石的治疗选择。本研究的目的是使用肝功能测试(LFT)和超声检查这种非侵入性方法来预测LC术前进行内镜逆行胰胆管造影(ERCP)的必要性。
在LC术前,对115例经超声检查确诊的有症状胆囊结石患者进行了LFT和ERCP检查。超声检查已发现有肿瘤或肝内胆管结石的患者被排除。根据超声检查结果将患者分为胆管树正常和扩张组,根据LFT(包括胆红素、碱性磷酸酶、γ-谷氨酰转移酶和淀粉酶)结果分为正常和异常组。
胆管超声和LFT均正常的患者中,97.6%的患者ERCP检查结果为阴性。超声检查发现胆管树扩张对ERCP检查发现的导管病变的阳性预测率为87%(40/46)。超声检查胆管树正常的患者中,ERCP检查发现导管病变阳性的发生率为17.4%(12/69)。单一LFT异常相当于ERCP检查发现导管病变的阳性预测率为68.8%。
对于超声检查胆管树正常且LFT正常的有症状胆囊结石患者,LC术前无需进行ERCP。超声检查胆管扩张或肝功能检查异常的患者确实需要进行ERCP检查。