Weinreb R N, Shakiba S, Sample P A, Shahrokni S, van Horn S, Garden V S, Asawaphureekorn S, Zangwill L
Glaucoma Center, University of California, San Diego, La Jolla 92093-0946, USA.
Am J Ophthalmol. 1995 Dec;120(6):732-8. doi: 10.1016/s0002-9394(14)72726-6.
To evaluate the association between quantitative nerve fiber layer measurements and visual field loss in patients with primary open-angle glaucoma.
Quantitative retinal nerve fiber layer measurements were obtained in 53 patients with primary open-angle glaucoma by using confocal scanning laser ophthalmoscopy (cross-section area) and confocal scanning laser polarimetry (retardation ratio). For each eye, three images were obtained with each instrument. An image that was the mean of those three was created and used in all analyses. We investigated the association between global, regional, and hemifield differences in retinal nerve fiber layer measurements and visual field loss with linear regression techniques.
The retardation ratio decreased with increasing mean visual field loss, measured both globally and regionally; R2 (the amount of variation explained by the model) ranged from 8% to 21%. Retinal nerve fiber layer cross-section area was not significantly associated with global measures of visual field loss. The inferior visual field mean deviation increased with decreasing superior retinal nerve fiber layer cross-section area (R2 = 8.2%, P = .04); superior visual field mean deviation was not associated with inferior retinal nerve fiber layer cross-section area (R2 = 2.6%, P = .25). Hemifield differences in visual field mean deviation increased with increasing hemifield differences in retinal nerve fiber layer cross-section area (R2 = 20.0%, P < .001), but not with retardation ratio (R2 = 0.9%, P = .48).
Quantitative measures of the retinal nerve fiber layer using both confocal scanning laser ophthalmoscopy and confocal scanning laser polarimetry were correlated with visual field loss in glaucoma patients.
评估原发性开角型青光眼患者定量神经纤维层测量值与视野缺损之间的关联。
采用共焦扫描激光检眼镜（测量横截面积）和共焦扫描激光偏振仪（测量延迟率）对53例原发性开角型青光眼患者进行视网膜神经纤维层定量测量。每种仪器对每只眼睛获取三张图像。创建这三张图像的平均值图像并用于所有分析。我们运用线性回归技术研究视网膜神经纤维层测量值的整体、区域和半视野差异与视野缺损之间的关联。
无论是整体还是区域测量，延迟率均随平均视野缺损的增加而降低；R²（模型解释的变异量）范围为8%至21%。视网膜神经纤维层横截面积与视野缺损的整体测量值无显著关联。下方视野平均偏差随上方视网膜神经纤维层横截面积的减小而增加（R² = 8.2%，P = 0.04）；上方视野平均偏差与下方视网膜神经纤维层横截面积无关联（R² = 2.6%，P = 0.25）。视野平均偏差的半视野差异随视网膜神经纤维层横截面积的半视野差异增加而增加（R² = 20.0%，P < 0.001），但与延迟率无关（R² = 0.9%，P = 0.48）。
使用共焦扫描激光检眼镜和共焦扫描激光偏振仪对视网膜神经纤维层进行的定量测量与青光眼患者的视野缺损相关。
