Niessen A G, Van Den Berg T J, Langerhorst C T, Greve E L
Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands.
Am J Ophthalmol. 1996 May;121(5):484-93. doi: 10.1016/s0002-9394(14)75422-4.
To determine whether, in a clinical setting, scanning laser polarimetry and retinal nerve fiber layer photography provide equivalent information on the retinal nerve fiber layer.
We prospectively studied 60 patients with glaucoma or ocular hypertension and 24 healthy subjects. With scanning laser polarimetry, an estimate of the cross section of the retinal nerve fiber layer was obtained. By using a photographic reference set, we quantified photographs of the retinal nerve fiber layer. Visual fields were used to relate the results of both methods to functional damage.
The scanning laser polarimetry measurements yielded reproducible cross-section values (coefficient of variation, 6.6%). Comparison of cross-section values and photograph scores gave Pearson correlation coefficients smaller than r = .4 (P < .01), improving to a maximum of r = .53 after compensation for offset. When cross-section values were compared to the mean deviation of the visual field, the Spearman correlation coefficients varied from an r of -.34 to -.53 (P < .01). Correction for offset resulted in an r of -.54 to -.65. When photograph scores and mean deviation of the visual field were compared, the Spearman correlation coefficients varied from an r of -.65 to -.71 (P < .01).
Because r was maximal at .53, the information on the retinal nerve fiber layer obtained with scanning laser polarimetry and photography seems not equivalent. This result could not have been because of lack of reproducibility. Although the results suggested possible offset in scanning laser polarimetry, other methodologic differences must be considered to explain the differences between the two techniques.
确定在临床环境中，扫描激光偏振仪和视网膜神经纤维层摄影术是否能提供关于视网膜神经纤维层的等效信息。
我们前瞻性地研究了60例青光眼或高眼压患者以及24名健康受试者。通过扫描激光偏振仪，获得了视网膜神经纤维层横截面的估计值。利用摄影参考集，我们对视网膜神经纤维层的照片进行了量化。视野用于将两种方法的结果与功能损害相关联。
扫描激光偏振仪测量得出了可重复的横截面值（变异系数为6.6%）。横截面值与照片评分的比较得出皮尔逊相关系数小于r = 0.4（P < 0.01），在补偿偏移后最大提高到r = 0.53。当将横截面值与视野的平均偏差进行比较时，斯皮尔曼相关系数在r = -0.34至 -0.53之间变化（P < 0.01）。校正偏移后r为 -0.54至 -0.65。当比较照片评分与视野的平均偏差时，斯皮尔曼相关系数在r = -0.65至 -0.71之间变化（P < 0.01）。
由于r最大为0.53，通过扫描激光偏振仪和摄影术获得的关于视网膜神经纤维层的信息似乎不等效。这个结果不可能是由于缺乏可重复性。尽管结果表明扫描激光偏振仪可能存在偏移，但必须考虑其他方法学差异来解释这两种技术之间的差异。
