Meyers S M, Greene T, Gutman F A
Division of Ophthalmology, Cleveland Clinic Foundation, OH 44195, USA.
Am J Ophthalmol. 1995 Dec;120(6):757-66. doi: 10.1016/s0002-9394(14)72729-1.
To determine the importance of genetic factors in age-related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic and dizygotic twin pairs.
We prospectively examined 134 consecutive twin pairs and two triplet sets for age-related macular degeneration. The zygosity was determined by genetic laboratory tests.
The concordance of age-related macular degeneration was 100% (25 of 25) in monozygotic and 42% (five of 12) in dizygotic twin pairs. The other twins or triplets had no macular changes of age-related macular degeneration.
The statistically significant higher concordance of age-related macular degeneration in monozygotic than in dizygotic twin pairs and the clinical heterogeneity of age-related macular degeneration strongly suggest the importance of genetic and nongenetic factors, respectively, in age-related macular degeneration.
通过一项双胞胎研究比较同卵双胞胎和异卵双胞胎中年龄相关性黄斑变性的一致性，以确定遗传因素在年龄相关性黄斑变性中的重要性。
我们前瞻性地检查了134对连续的双胞胎和两组三胞胎是否患有年龄相关性黄斑变性。通过基因实验室检测确定合子性。
同卵双胞胎中年龄相关性黄斑变性的一致性为100%（25对中的25对），异卵双胞胎中为42%（12对中的5对）。其他双胞胎或三胞胎没有年龄相关性黄斑变性的黄斑变化。
同卵双胞胎中年龄相关性黄斑变性的一致性在统计学上显著高于异卵双胞胎，以及年龄相关性黄斑变性的临床异质性分别强烈提示了遗传因素和非遗传因素在年龄相关性黄斑变性中的重要性。
