Rabbia F, Veglio F, Russo R, Schiavone D, Oliva S, Chiandussi L
Department of Medicine and Experimental Oncology, University of Turin S. Vito Hospital, Italy.
Alcohol Alcohol. 1995 Jul;30(4):433-9.
To evaluate the importance of alcohol and other environmental factors in essential hypertensives, we conducted a cross-sectional study on 627 patients (322 women, 305 men) subdivided in four subgroups according to sex and presence or absence of drug therapy, to evaluate differences due to drugs and changes in life style. Multiple regression analyses were run where systolic and diastolic blood pressures were considered as separate dependent variables with the following independent variables: age, body mass index, physical activity, alcohol and coffee consumption, smoking, educational level; considered as continuous or categorical variables. eighty-eight per cent of all patients showed a moderate-low alcohol intake (1-50 g/day); wine was the preferred beverage. We found a negative independent relationship between mild/moderate alcohol consumption levels and systolic blood pressure in untreated men and untreated women, and no relationship between alcohol and diastolic blood pressure in all subgroups considered. Body mass index and age were positively associated with both systolic and diastolic blood pressure. Our data suggest that mild to moderate alcohol consumption does not affect blood pressure control in either treated or untreated hypertensive patients.
为评估酒精及其他环境因素在原发性高血压患者中的重要性,我们对627例患者(322例女性,305例男性)进行了一项横断面研究。根据性别及是否接受药物治疗将患者分为四个亚组,以评估药物及生活方式改变所造成的差异。进行多元回归分析时,将收缩压和舒张压作为单独的因变量,以下变量作为自变量:年龄、体重指数、体力活动、酒精和咖啡摄入量、吸烟状况、教育程度;这些变量视为连续变量或分类变量。所有患者中88%酒精摄入量为低至中度(1 - 50克/天);葡萄酒是首选饮品。我们发现,未接受治疗的男性和女性中,轻度/中度酒精摄入量与收缩压之间存在负向独立关系,且在所有研究的亚组中,酒精与舒张压之间均无关联。体重指数和年龄与收缩压和舒张压均呈正相关。我们的数据表明,轻度至中度饮酒对接受治疗或未接受治疗的高血压患者的血压控制均无影响。