Hofkin G A, Ting C D
Sinai Hospital, Baltimore, USA.
Md Med J. 1995 Dec;44(12):1047-8.
An association between cytomegalovirus (CMV) and idiopathic ulcerative colitis has been known for more than 30 years. The CMV-associated colitis usually occurs in those who are either immunosuppressed or taking long-term corticosteroid drugs. We describe a patient who had been diagnosed with ulcerative colitis, who then developed a recurrence six months after glucocorticoid therapy was started. Despite tapering or increasing the glucocorticoid therapy, the symptoms did not improve. Investigations demonstrated the presence of CMV in tissue samples, increase in antibody titers to the CMV virus, and resolution of the colitis upon use of specific anti-CMV therapy.
巨细胞病毒（CMV）与特发性溃疡性结肠炎之间的关联已为人所知超过30年。CMV相关性结肠炎通常发生在免疫抑制或长期服用皮质类固醇药物的人群中。我们描述了一名被诊断为溃疡性结肠炎的患者，在开始糖皮质激素治疗6个月后病情复发。尽管调整了糖皮质激素治疗的剂量（减量或增量），症状仍未改善。检查显示组织样本中存在CMV，抗CMV病毒抗体滴度升高，且使用特异性抗CMV治疗后结肠炎得到缓解。
