Keren D F, Milligan F D, Strandberg J D, Yardley J H
Johns Hopkins Med J. 1975 Apr;136(4):178-82.
Acute intercurrent CMV colitis developed in a patient with UC who was receiving prednisone. CMV infection was suggested by light and electron microscopic study of a rectal biopsy taken during the acute episode and was confirmed by serology done nine months later. The microscopic studies of plastic-embedded tissues demonstrated that infected cells were concentrated in a subendothelial location and were presumably macrophages. Epithelial and endothelial cells were not involved. Steroid therapy and the inflammation and repair process (granulartion tissue) of active UC may have predisposed the present patient to CMV colitis. CMV infection has been reported to be more common in patients with UC than in the general population. Detection of CMV colitis in patients with UC could be of special importance since alteration of immunosuppressive therapy may be indicated.
一名正在接受泼尼松治疗的溃疡性结肠炎（UC）患者发生了急性并发巨细胞病毒（CMV）结肠炎。急性发作期间采集的直肠活检组织经光镜和电镜检查提示CMV感染，并在9个月后通过血清学检查得以证实。对塑料包埋组织的显微镜研究表明，受感染细胞集中在内皮下位置，推测为巨噬细胞。上皮细胞和内皮细胞未受累。类固醇治疗以及活动性UC的炎症和修复过程（肉芽组织）可能使该患者易患CMV结肠炎。据报道，UC患者中CMV感染比普通人群更常见。在UC患者中检测CMV结肠炎可能特别重要，因为这可能提示免疫抑制治疗方案的调整。
