Tourniaire J, Guichard-Rode S, Monier J C
Clinique Endocrinologique, Hôpital de l'Antiquaille, Lyon.
Presse Med. 1995 Oct 21;24(31):1425-7.
The level of circulating antigliadin antibodies is an essential element in diabetic patients with signs of coeliac disease. Intolerance to gluten can disrupt glucose regulation leading to greater risk of hypoglycaemia. Search for antigliadin antibodies could be a routine test in diabetics.
Plasma gliadin antibodies were measured by immunoenzymatic assay in adult subjects: 80 type 1 diabetics, 80 type 2 diabetics, 80 non diabetics without auto-immune disease.
IgA antibodies were present in 6 type 1 diabetics (7.5%), 8 type 2 diabetics (10%) and 6 non-diabetics (7.5%). Anti-reticulin and anti-endomysium antibodies were measured in type 1 diabetics with antigliadine antibodies. They were present only in one patient (Tunisian) who suffered from a coeliac disease.
In France, the prevalence of coeliac disease is very low. Antigliadin antibodies measurement is justified only in patients with clinical and/or biological symptoms of coeliac disease.
循环抗麦醇溶蛋白抗体水平是患有乳糜泻体征的糖尿病患者的一个关键要素。麸质不耐受会扰乱血糖调节，导致低血糖风险增加。对糖尿病患者进行抗麦醇溶蛋白抗体检测可能成为一项常规检查。
采用免疫酶法对成年受试者进行血浆麦醇溶蛋白抗体检测：80例1型糖尿病患者、80例2型糖尿病患者、80例无自身免疫性疾病的非糖尿病患者。
6例1型糖尿病患者（7.5%）、8例2型糖尿病患者（10%）和6例非糖尿病患者（7.5%）体内存在IgA抗体。对存在抗麦醇溶蛋白抗体的1型糖尿病患者检测了抗网硬蛋白抗体和抗肌内膜抗体。仅在1例患有乳糜泻的患者（突尼斯人）体内检测到这些抗体。
在法国，乳糜泻的患病率非常低。仅在患有乳糜泻临床和/或生物学症状的患者中进行抗麦醇溶蛋白抗体检测才合理。
