儿童乳糜泻与胰岛素依赖型糖尿病的共存：使用酶联免疫吸附测定法检测麦醇溶蛋白抗体的筛查血清

Co-existence of coeliac disease and insulin-dependent diabetes mellitus in children: screening sera using an ELISA test for gliadin antibody.

作者信息

Gadd S, Kamath K R, Silink M, Skerritt J H

机构信息

Royal Alexandra Hospital for Children, Sydney, NSW, Australia.

出版信息

Aust N Z J Med. 1992 Jun;22(3):256-60. doi: 10.1111/j.1445-5994.1992.tb02121.x.

DOI:10.1111/j.1445-5994.1992.tb02121.x

PMID:1497552

Abstract

The prevalence of coeliac disease in children with insulin-dependent diabetes mellitus was investigated using a screening test of serum for antigliadin antibody by ELISA. One hundred and eighty (180) unselected diabetic children were screened for IgA and IgG class antigliadin antibodies (AGA); children with either grossly elevated or slightly elevated AGA had small bowel biopsies. The four children with the highest IgA AGA had total villous atrophy. These four children were considered to have unsuspected coeliac disease. The prevalence of coeliac disease in this group of children was one in 45. Anti-gliadin IgA and IgG tests are suitable for screening children at high risk of having coeliac disease.

摘要

采用酶联免疫吸附测定法（ELISA）检测血清抗麦醇溶蛋白抗体，对胰岛素依赖型糖尿病患儿的乳糜泻患病率进行了调查。对180名未经挑选的糖尿病患儿进行了IgA和IgG类抗麦醇溶蛋白抗体（AGA）筛查；AGA显著升高或轻度升高的患儿接受了小肠活检。IgA AGA水平最高的4名患儿出现了完全性绒毛萎缩。这4名患儿被认为患有隐匿性乳糜泻。该组儿童中乳糜泻的患病率为1/45。抗麦醇溶蛋白IgA和IgG检测适用于对患乳糜泻高危儿童进行筛查。