Fujimoto T, Nakano T, Takano T, Hokazono Y, Asakura T, Tsuji T
Department of Psychiatry, South Japan Health Science Centre, Fujimoto Hospital.
Acta Psychiatr Scand. 1992 Dec;86(6):455-62. doi: 10.1111/j.1600-0447.1992.tb03297.x.
Phosphorus-31 chemical shift imaging showed regional abnormalities of in vivo 31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of % gamma alpha beta-ATP (obtained by summation of gamma-ATP, alpha-ATP, and beta-ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of % gamma alpha beta-ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high-energy phosphate metabolism in the specific cerebral regions.
磷-31化学位移成像显示，慢性精神分裂症患者大脑中体内31P NMR谱存在区域异常。在左侧颞叶区域，磷酸二酯（PDE）百分比水平升高，γ-α-β-ATP（通过γ-ATP、α-ATP和β-ATP总和获得）百分比水平降低。在基底神经节，PDE百分比水平降低，磷酸单酯百分比水平升高。右侧基底神经节中γ-α-β-ATP百分比水平升高。额顶叶区域磷酸肌酸百分比水平降低。这些发现可能代表特定脑区膜磷脂双层和高能磷酸代谢功能障碍的不同模式。
