Fukuzako H, Takeuchi K, Hokazono Y, Fukuzako T, Yamada K, Hashiguchi T, Obo Y, Ueyama K, Takigawa M, Fujimoto T
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Psychiatry Res. 1995 Nov 10;61(4):193-200. doi: 10.1016/0925-4927(95)02622-5.
Proton magnetic resonance spectroscopy (MRS) was performed in 30 medicated schizophrenic patients and 30 normal subjects. Two groups, each containing 15 schizophrenic patients and 15 age-and sex-matched normal subjects, received MRS examinations for different volumes of interest, either the frontal lobe or the medial temporal lobe. Schizophrenic patients showed a decrease in the ratios of N-acetylaspartate (NAA)/choline-containing compounds (Cho) and NAA/creatine-phosphocreatine (Cr). The patients also showed an increase in the ratio of Cho/Cr in the left medial temporal lobe but not in the left frontal lobe. The age at onset of illness correlated positively with the ratios of NAA/Cho and NAA/Cr in the medial temporal lobe. No significant correlation was observed between the ratios of NAA/Cho, NAA/Cr, or Cho/Cr in the left medial temporal and frontal lobes and clinical symptomatology as assessed by the Scale for the Assessment of Negative Symptoms and the Positive and Negative Syndrome Scale.
对30例接受药物治疗的精神分裂症患者和30名正常受试者进行了质子磁共振波谱（MRS）检查。将两组，每组包含15例精神分裂症患者和15名年龄及性别匹配的正常受试者，分别针对不同感兴趣区域（额叶或内侧颞叶）进行MRS检查。精神分裂症患者的N-乙酰天门冬氨酸（NAA）/含胆碱化合物（Cho）以及NAA/肌酸-磷酸肌酸（Cr）的比值降低。患者左侧内侧颞叶的Cho/Cr比值升高，但左侧额叶未出现这种情况。发病年龄与内侧颞叶的NAA/Cho和NAA/Cr比值呈正相关。通过阴性症状评定量表和阳性与阴性症状量表评估发现，左侧内侧颞叶和额叶的NAA/Cho、NAA/Cr或Cho/Cr比值与临床症状之间未观察到显著相关性。
