免疫接种与婴儿猝死综合征。新西兰婴儿猝死研究小组。
Immunisation and the sudden infant death syndrome. New Zealand Cot Death Study Group.
作者信息
Mitchell E A, Stewart A W, Clements M
机构信息
University of Auckland, Department of Paediatrics, New Zealand.
出版信息
Arch Dis Child. 1995 Dec;73(6):498-501. doi: 10.1136/adc.73.6.498.
AIMS
To examine the relation between immunisation and the risk of sudden infant death syndrome (SIDS).
METHODS
A large nationwide case-control study. Parental held records were used to measure immunisation status.
RESULTS
Infants were at increased risk of SIDS if they had not received the 6 week, 3 month, and 5 month immunisations. After controlling for potential confounding variables, including those which measured health care use and infant illness, the relative risk of SIDS for infants not being immunised at 6 weeks was 2.1 (95% confidence interval = 1.2, 3.5). Four percent of cases died within four days of immunisation and 7.6% of control infants had been immunised within four days of the nominated date. There was a reduced chance of SIDS in the four days immediately following immunisation (OR = 0.5; 95% CI = 0.2 to 0.9).
CONCLUSIONS
Immunisation does not increase the risk of SIDS and may even lower the risk.
目的
研究免疫接种与婴儿猝死综合征（SIDS）风险之间的关系。
方法
一项大规模的全国性病例对照研究。利用家长保存的记录来衡量免疫接种状况。
结果
未接受6周、3个月和5个月龄免疫接种的婴儿患SIDS的风险增加。在控制了潜在的混杂变量，包括那些衡量医疗保健利用情况和婴儿疾病的变量后，6周龄时未进行免疫接种的婴儿患SIDS的相对风险为2.1（95%置信区间=1.2, 3.5）。4%的病例在免疫接种后四天内死亡，7.6%的对照婴儿在指定日期后四天内进行了免疫接种。免疫接种后紧接着的四天内发生SIDS的几率降低（比值比=0.5；95%置信区间=0.2至0.9）。
结论
免疫接种不会增加SIDS的风险，甚至可能降低风险。
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