Smirnov V V, Bondarenko A S, Petrenko G T, Prikhod'ko V A, Evseenko O V, Pavlenko L V
Mikrobiol Z. 1995 Jul-Aug;57(4):73-82.
Data of in vitro and in vivo investigations of antimicrobial activity of preparation K carried out both by the authors and by other researchers and pharmacological properties of this preparation have been summarized. Preparation K has been obtained from medicinal plant of the Asteraceae family. It is a natural composition of two antibiotics and of a number of minor compounds. The preparation possesses a wide spectrum of biological action. It is antimicrobially active against gram-positive bacteria, some species of gram-negative bacteria, fungi-dermatophytes including antibiotic-resistant strains. It is not toxic for animals, stimulates some defensive reactions of macroorganism, has immunomodulating, anti-inflammatory, anti-exudative, keratolytic properties. Preparation K is efficient for treatment of experimental mycoses of animals and is clinically tested as a local agent for treatment of dermatomycoses.
作者及其他研究人员对制剂K的抗菌活性进行的体外和体内研究数据以及该制剂的药理特性已被总结。制剂K是从菊科药用植物中获得的。它是两种抗生素和许多次要化合物的天然组合物。该制剂具有广泛的生物活性。它对革兰氏阳性菌、一些革兰氏阴性菌、包括抗药菌株在内的皮肤真菌具有抗菌活性。它对动物无毒，刺激机体的一些防御反应，具有免疫调节、抗炎、抗渗出、角质溶解特性。制剂K对动物实验性真菌病的治疗有效，并作为治疗皮肤真菌病的局部药物进行了临床试验。
