Lipman R D, Chrisp C E, Hazzard D G, Bronson R T
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA.
J Gerontol A Biol Sci Med Sci. 1996 Jan;51(1):B54-9. doi: 10.1093/gerona/51a.1.b54.
The rat is a common laboratory animal utilized in a variety of investigations including experimental gerontology. Gerontologic investigations can be compromised when the differences observed when comparing young and old animals are actually differences between normal and disease states. It is of critical interest to know the pathology of the animals being studied and to understand the impact of these disease processes on the parameters being measured. The incidence and average age of occurrence for lesions have been characterized and are reported here for one inbred (Brown Norway) and two hybrid strains (Brown Norway x Fischer 344 and Fischer 344 x Brown Norway) of rat. Total lesion incidence functions as a biomaker of aging for all of the strains examined (p < or = .00001). These three genotypes have significantly lower incidence of several major pathologic processes (including glomerulonephritis, retinal atrophy, and leukemia) than do the Fischer 344 and the Wistar rats, two commonly utilized strains. Additionally, the BN and F344 x BN F1 hybrid attain 50% mortality at 130 and 146 weeks of age, respectively, which is significantly greater than the 103 weeks for the F344 rat. It is hoped that access to basic information on these three rat genotypes will increase their utilization by the community of gerontologic scientists.
大鼠是一种常见的实验动物，用于包括实验老年学在内的各种研究。当比较年轻和年老动物时观察到的差异实际上是正常状态和疾病状态之间的差异时，老年学研究可能会受到影响。了解所研究动物的病理学并理解这些疾病过程对所测量参数的影响至关重要。本文报道了一种近交系（棕色挪威大鼠）和两种杂交品系（棕色挪威大鼠×费希尔344大鼠和费希尔344大鼠×棕色挪威大鼠）大鼠的病变发生率和平均发病年龄。在所检查的所有品系中，总病变发生率可作为衰老的生物标志物（p≤0.00001）。这三种基因型的几种主要病理过程（包括肾小球肾炎、视网膜萎缩和白血病）的发生率明显低于两种常用品系费希尔344大鼠和Wistar大鼠。此外，棕色挪威大鼠和费希尔344大鼠×棕色挪威大鼠F1杂交种分别在130周和146周龄时达到50%的死亡率，这明显高于费希尔344大鼠的103周龄。希望这些关于三种大鼠基因型的基础信息能增加老年学科学家群体对它们的利用。
