肌腱疾病转化治疗的进展。
Advances toward transformative therapies for tendon diseases.
机构信息
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
出版信息
Sci Transl Med. 2022 Sep 7;14(661):eabl8814. doi: 10.1126/scitranslmed.abl8814.
Abstract
Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies. Shifting from targeting symptom relief toward disease modification and prevention of disease progression may open new avenues for therapies. Deep evidence-based clinical, cellular, and molecular characterization of the underlying pathology of tendon diseases, as well as therapeutic delivery optimization and establishment of multidiscipline interorganizational collaboration platforms, may accelerate the discovery and translation of transformative therapies for tendon diseases.
摘要
经批准的肌腱疾病治疗方法尚未改变针对症状性疼痛治疗和物理疗法的临床实践。本文综述了新型药物、生物制品和生物材料治疗肌腱疾病方面的进展，并展望了综合治疗的转化。从以缓解症状为目标转向疾病的改变和预防疾病的进展，可能为治疗开辟新的途径。深入的基于证据的肌腱疾病基础病理的临床、细胞和分子特征，以及治疗传递优化和建立多学科组织间合作平台，可能加速肌腱疾病变革性治疗的发现和转化。
相似文献
1
Advances toward transformative therapies for tendon diseases.肌腱疾病转化治疗的进展。
Sci Transl Med. 2022 Sep 7;14(661):eabl8814. doi: 10.1126/scitranslmed.abl8814.
2
[Precise application of Traditional Chinese Medicine in minimally-invasive techniques].[中医在微创技术中的精准应用]
Zhongguo Gu Shang. 2018 Jun 25;31(6):493-496. doi: 10.3969/j.issn.1003-0034.2018.06.001.
3
Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework.探讨肌腱内压力在肌腱病发病机制中的作用：叙述性综述和概念框架。
Br J Sports Med. 2023 Aug;57(16):1042-1048. doi: 10.1136/bjsports-2022-106066. Epub 2022 Nov 2.
4
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies.间充质干细胞赋能肌腱再生疗法。
Int J Mol Sci. 2019 Jun 19;20(12):3002. doi: 10.3390/ijms20123002.
5
A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration.肌腱损伤与再生的临床、生物学及生物材料视角
Tissue Eng Part B Rev. 2017 Feb;23(1):44-58. doi: 10.1089/ten.TEB.2016.0181. Epub 2016 Sep 30.
6
Tendon cell and tissue culture: Perspectives and recommendations.肌腱细胞与组织培养：观点与建议。
J Orthop Res. 2023 Oct;41(10):2093-2104. doi: 10.1002/jor.25532. Epub 2023 Feb 27.
7
Combined Anterior Latissimus Dorsi and Teres Major Tendon Transfer (aLDTM) for Irreparable Anterosuperior Rotator Cuff Tears.联合背阔肌和大圆肌腱转位术（aLDTM）治疗不可修复的肩袖前上部分撕裂
JBJS Essent Surg Tech. 2024 Apr 19;14(2). doi: 10.2106/JBJS.ST.23.00060. eCollection 2024 Apr-Jun.
8
Tendon Aging.肌腱老化
Subcell Biochem. 2023;103:121-147. doi: 10.1007/978-3-031-26576-1_7.
9
Nanoparticle-coated sutures providing sustained growth factor delivery to improve the healing strength of injured tendons.纳米颗粒包被的缝线可提供持续的生长因子递送，以提高受损肌腱的愈合强度。
Acta Biomater. 2021 Apr 1;124:301-314. doi: 10.1016/j.actbio.2021.01.008. Epub 2021 Jan 11.
10
Alterations of tendons in diabetes mellitus: what are the current findings?糖尿病中肌腱的改变：当前有哪些发现？
Int Orthop. 2015 Aug;39(8):1465-73. doi: 10.1007/s00264-015-2775-x. Epub 2015 May 6.
引用本文的文献
1
Graft Treatment for Rotator Cuff Tendon-Bone Interface Augmentation: Status and Prospects-A Narrative Review.用于肩袖肌腱-骨界面增强的移植治疗：现状与展望——一篇叙述性综述
Clin Orthop Surg. 2025 Aug;17(4):557-567. doi: 10.4055/cios24490. Epub 2025 Jul 15.
2
A Narrative Review on the Double Pulley-Triple Row Technique for Large to Massive Rotator Cuff Repair.关于用于大到巨大肩袖损伤修复的双滑轮-三排技术的叙述性综述
Clin Orthop Surg. 2025 Jun;17(3):359-371. doi: 10.4055/cios24424. Epub 2025 May 15.
3
Fat Expansion Not Fat Infiltration of Muscle Post Rotator Cuff Tendon Tears of the Shoulder: Regenerative Engineering Implications.肩袖肌腱撕裂后肌肉的脂肪扩张而非脂肪浸润：对再生工程的启示
Regen Eng Transl Med. 2025 Mar;11(1):1-14. doi: 10.1007/s40883-023-00324-y. Epub 2023 Nov 27.
4
Platelet-rich plasma and corticosteroid injection for tendinopathy: a systematic review and meta-analysis.富血小板血浆和皮质类固醇注射治疗肌腱病：一项系统评价和荟萃分析。
BMC Musculoskelet Disord. 2025 Apr 8;26(1):339. doi: 10.1186/s12891-025-08566-3.
5
Achilles tendinopathy.跟腱病
Nat Rev Dis Primers. 2025 Mar 27;11(1):20. doi: 10.1038/s41572-025-00602-9.
6
Transcriptome-Optimized Hydrogel Design of a Stem Cell Niche for Enhanced Tendon Regeneration.用于增强肌腱再生的干细胞微环境的转录组优化水凝胶设计
Adv Mater. 2025 Jan;37(2):e2313722. doi: 10.1002/adma.202313722. Epub 2024 Oct 17.
7
Antifibrotic and Pro-regenerative Effects of SMAD3 siRNA and Collagen I mRNA-Loaded Lipid Nanoparticles in Human Tenocytes.SMAD3小干扰RNA和负载I型胶原蛋白信使核糖核酸的脂质纳米颗粒对人肌腱细胞的抗纤维化和促再生作用
ACS Appl Nano Mater. 2024 Jul 18;7(15):17736-17747. doi: 10.1021/acsanm.4c02996. eCollection 2024 Aug 9.
8
Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing.基于纳米颗粒的肌腱靶向药物传递系统的开发，以药理学方式调节肌腱愈合。
Sci Adv. 2024 Jun 21;10(25):eadn2332. doi: 10.1126/sciadv.adn2332. Epub 2024 Jun 19.
9
Study of the Synergistic Immunomodulatory and Antifibrotic Effects of Dual-Loaded Budesonide and Serpine1 siRNA Lipid-Polymer Nanoparticles Targeting Macrophage Dysregulation in Tendinopathy.双联载布地奈德和丝氨酸蛋白酶抑制剂 1 siRNA 脂质-聚合物纳米粒靶向调控肌腱病中巨噬细胞紊乱的协同免疫调节和抗纤维化作用研究。
ACS Appl Mater Interfaces. 2024 Apr 17;16(15):18643-18657. doi: 10.1021/acsami.4c02363. Epub 2024 Apr 2.
10
Engineering an extracellular matrix-functionalized, load-bearing tendon substitute for effective repair of large-to-massive tendon defects.构建一种细胞外基质功能化的承重肌腱替代物，用于有效修复大至巨大的肌腱缺损。
Bioact Mater. 2024 Mar 5;36:221-237. doi: 10.1016/j.bioactmat.2024.02.032. eCollection 2024 Jun.
本文引用的文献
1
Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior.衰老和基质粘弹性会影响肌腱的多尺度性质和肌腱衍生细胞的行为。
Acta Biomater. 2022 Apr 15;143:63-71. doi: 10.1016/j.actbio.2022.03.006. Epub 2022 Mar 9.
2
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.具有粘附侧和高载药能力的坚韧水凝胶增强肌腱愈合。
Nat Biomed Eng. 2022 Oct;6(10):1167-1179. doi: 10.1038/s41551-021-00810-0. Epub 2022 Jan 3.
3
Evaluating lower limb tendinopathy with Victorian Institute of Sport Assessment (VISA) questionnaires: a systematic review shows very-low-quality evidence for their content and structural validity-part I.用维多利亚州运动研究所评估（VISA）问卷评估下肢腱病：系统评价显示其内容和结构效度的证据质量极低——第 1 部分。
Knee Surg Sports Traumatol Arthrosc. 2021 Sep;29(9):2749-2764. doi: 10.1007/s00167-021-06598-5. Epub 2021 May 21.
4
Kinetic degradation and biocompatibility evaluation of polycaprolactone-based biologics delivery matrices for regenerative engineering of the rotator cuff.基于聚己内酯的生物降解材料在肩袖再生工程中的药物控释及生物相容性评价。
J Biomed Mater Res A. 2021 Nov;109(11):2137-2153. doi: 10.1002/jbm.a.37200. Epub 2021 May 11.
5
Why do some inter-organisational collaborations in healthcare work when others do not? A realist review.为什么有些医疗保健领域的组织间合作能够成功，而有些则不能？一项现实主义综述。
Syst Rev. 2021 Mar 22;10(1):82. doi: 10.1186/s13643-021-01630-8.
6
mRNA vaccine for cancer immunotherapy.用于癌症免疫治疗的信使核糖核酸疫苗
Mol Cancer. 2021 Feb 25;20(1):41. doi: 10.1186/s12943-021-01335-5.
7
Tendinopathy.腱病。
Nat Rev Dis Primers. 2021 Jan 7;7(1):1. doi: 10.1038/s41572-020-00234-1.
8
Enhancing anti-tumour efficacy with immunotherapy combinations.免疫疗法联合增强抗肿瘤疗效。
Lancet. 2021 Mar 13;397(10278):1010-1022. doi: 10.1016/S0140-6736(20)32598-8. Epub 2020 Dec 4.
9
Relationship between tendon structure, stiffness, gait patterns and patient reported outcomes during the early stages of recovery after an Achilles tendon rupture.跟腱结构、硬度、步态模式与跟腱断裂康复早期患者报告结局之间的关系。
Sci Rep. 2020 Nov 27;10(1):20757. doi: 10.1038/s41598-020-77691-x.
10
Engineered Cell Sheets for the Effective Delivery of Adipose-Derived Stem Cells for Tendon-to-Bone Healing.用于有效递送至腱骨愈合的脂肪来源干细胞的工程化细胞片。
Am J Sports Med. 2020 Nov;48(13):3347-3358. doi: 10.1177/0363546520964445. Epub 2020 Oct 14.
Zotero 插件