将基于重量的抗体单位分配给人抗肺炎球菌标准参考血清，批号89-S。
Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, lot 89-S.
作者信息
Quataert S A, Kirch C S, Wiedl L J, Phipps D C, Strohmeyer S, Cimino C O, Skuse J, Madore D V
机构信息
Lederle-Praxis Biologicals, West Henrietta, New York 14586-9728, USA.
出版信息
Clin Diagn Lab Immunol. 1995 Sep;2(5):590-7. doi: 10.1128/cdli.2.5.590-597.1995.
Abstract
A human reference serum pool, lot 89-S, has been developed for use in quantitating concentrations of antibody to Streptococcus pneumoniae. Weight-based units have been assigned to antibodies to 11 pneumococcal polysaccharide (PnPs) serotypes (1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F) by using enzyme-linked immunosorbent assay methodology and a human standard reference serum, USNRP IS 1644. The experimentally derived assignments for anti-PnPs antibodies of the immunoglobulin G (IgG), IgM, and IgA isotypes in lot 89-S correlate well to the separately determined immunoglobulin assignment. These assignments for this antipneumococcal standard serum were used to quantitate IgG, IgM, and IgA isotype levels and the total immunoglobulin level in pediatric samples from a pneumococcal conjugate vaccine trial. The data indicate that these assignments may be used to assess levels of antibody to PnPs serotypes in human serum.
摘要
已开发出一批89 - S的人参考血清库，用于定量检测抗肺炎链球菌抗体的浓度。通过酶联免疫吸附测定方法和人标准参考血清USNRP IS 1644，已为11种肺炎球菌多糖（PnP）血清型（1、3、4、5、6B、7F、9V、14、18C、19F和23F）的抗体指定了基于重量的单位。批次89 - S中免疫球蛋白G（IgG）、IgM和IgA同种型的抗PnP抗体的实验性指定与单独测定的免疫球蛋白指定高度相关。该抗肺炎球菌标准血清的这些指定用于定量肺炎球菌结合疫苗试验中儿科样本中的IgG、IgM和IgA同种型水平以及总免疫球蛋白水平。数据表明，这些指定可用于评估人血清中抗PnP血清型的抗体水平。
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