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高危人群中的人类T细胞白血病病毒II型感染及其对HIV-1疾病进展的影响。

Human T-cell leukemia virus type II infection among high risk groups and its influence on HIV-1 disease progression.

作者信息

Giacomo M, Franco E G, Claudio C, Carlo C, Anna D A, Anna D, Franco F

机构信息

Cattedra di Malattie Infettive, Università degli Studi di Parma, Italy.

出版信息

Eur J Epidemiol. 1995 Oct;11(5):527-33. doi: 10.1007/BF01719304.

DOI:10.1007/BF01719304
PMID:8549726
Abstract

The prevalence and the risk factors of the human T-cell leukemia virus type I/II (HTLV-I/II) infection were evaluated among 552 individuals at high risk for HIV-1. HTLV infections showed a low (1.6%) prevalence, were restricted to intravenous drug addicts and were due to HTLV-II alone. Moreover, in order to weigh the influence of HTLV-II on the natural history of HIV-1 infection, the clinical outcome of HIV-1 disease was compared between subjects with and without HTLV-II coinfection. Our findings showed that HTLV-II does not adversely affect the outcome of HIV-1 infection. Infact, a slower disease progression has been recorded in some HTLV-II coinfected subjects.

摘要

在552名感染人类免疫缺陷病毒1型(HIV-1)风险较高的个体中,对人类嗜T淋巴细胞病毒I/II型(HTLV-I/II)感染的患病率和危险因素进行了评估。HTLV感染的患病率较低(1.6%),仅局限于静脉注射吸毒者,且均由HTLV-II引起。此外,为了权衡HTLV-II对HIV-1感染自然史的影响,对合并感染HTLV-II和未合并感染HTLV-II的HIV-1感染者的临床结局进行了比较。我们的研究结果表明,HTLV-II不会对HIV-1感染的结局产生不利影响。事实上,在一些合并感染HTLV-II的受试者中,疾病进展较为缓慢。

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