Soriano V, Vallejo A, Gutiérrez M, Tuset C, Cilla G, Martínez-Zapico R, Dronda F, Caballero E, Calderón E, Aguilera A, Martín A M, Llibre J, del Romero J, Ortiz de Lejarazu R, Ulloa F, Eirós J, González-Lahoz J
Centro de Investigaciones Clínicas, Instituto de Salud Carlos III, Madrid, Spain.
Eur J Epidemiol. 1996 Dec;12(6):625-9. doi: 10.1007/BF00499462.
The human T-lymphotropic virus type II (HTLV-II) has recently been associated with the genesis of some subacute neurological syndromes and, rarely, with atypical T-lymphoid malignancies. The virus is endemic in some Amerindian and African tribes, and among intravenous drug users (IDUs) in North America and Europe. Given that HTLV-II is transmitted by the same routes as other human retroviruses, the screening of antibodies to HTLV-II in blood donors has became a matter of controversy in some countries. Herein, we describe the clinical, epidemiological and virological features of 113 individuals with HTLV-II infection identified in Spain up to September 1995. Most of them (94/113; 83%) were male, and all but seven were natives. Four were African immigrants living in Madrid and 3 had been born in other European countries. All but six subjects were IDUs, and sexual transmission of HTLV-II and transfusion were involved in five and one individual, respectively. Eighty-four percent of the IDUs infected with HTLV-II were co-infected by HIV-I (93/107). Clinical manifestations potentially linked to HTLV-II were absent, although an IDU male co-infected by HIV-1 and HTLV-II developed a severe non-inflammatory proximal myopathy. In conclusion, HTLV-II infection is present in Spain, mainly among IDUs, with a growing incidence and a current overall prevalence of 2.0 percent.
人类嗜T淋巴细胞病毒II型（HTLV-II）最近被认为与一些亚急性神经综合征的发生有关，并且很少与非典型T淋巴细胞恶性肿瘤相关。该病毒在一些美洲印第安人和非洲部落中流行，在北美和欧洲的静脉注射吸毒者（IDU）中也有发现。鉴于HTLV-II与其他人类逆转录病毒通过相同途径传播，在一些国家，对献血者进行HTLV-II抗体筛查已成为一个有争议的问题。在此，我们描述了截至1995年9月在西班牙确定的113例HTLV-II感染个体的临床、流行病学和病毒学特征。他们中的大多数（94/113；83%）为男性，除7人外均为本地人。4人为居住在马德里的非洲移民，3人出生于其他欧洲国家。除6人外，所有受试者均为静脉注射吸毒者，HTLV-II的性传播和输血传播分别涉及5人和1人。感染HTLV-II的静脉注射吸毒者中有84%同时感染了HIV-I（93/107）。虽然一名同时感染HIV-1和HTLV-II的静脉注射吸毒男性出现了严重的非炎性近端肌病，但未发现与HTLV-II潜在相关的临床表现。总之，HTLV-II感染在西班牙存在，主要发生在静脉注射吸毒者中，发病率不断上升，目前总体患病率为2.0%。
