Bruinse H W, van den Berg H
Department of Obstetrics and Gynecology, University Hospital Utrecht, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1995 Jul;61(1):31-7. doi: 10.1016/0028-2243(95)02150-q.
Most vitamin status parameters change significantly during pregnancy. A number of factors have been associated with this hypovitaminaemia of pregnancy. From our data, it was concluded that the initial value of a vitamin status parameter was by far the main determinant of the changes of vitamin levels during pregnancy: the higher the value, the steeper the decrease. Some hormonal variables were associated with these changes as well. This is highly suggestive of a resetting of vitamin homeostasis in blood, with a retention of vitamins in maternal tissues. The postpartum changes of vitamin levels provide insight into the 'net cost' of vitamins during pregnancy. Most serum blood levels of vitamins normalized shortly after delivery. Serum vitamin B6 levels increased slowly with 25% below the acceptable range at 6 months postpartum. However, the GGOT stimulation ratio, indicative for vitamin B6 cellular content, was completely normal at the time. Serum folacin was the only exception, with 45% serum levels in the marginal or deficient range; 20% of this group had deficient or marginal red cell folacin levels as well. This indicates that the 'net cost' of folacin during pregnancy is considerable, and repletion of folacin stores takes more than 6 months.
大多数维生素状态参数在孕期会发生显著变化。许多因素与孕期维生素缺乏血症有关。从我们的数据来看，得出的结论是，维生素状态参数的初始值是孕期维生素水平变化的主要决定因素：该值越高，下降幅度越大。一些激素变量也与这些变化有关。这强烈表明血液中维生素稳态发生了重置，维生素在母体组织中潴留。产后维生素水平的变化有助于了解孕期维生素的“净消耗”情况。大多数维生素的血清水平在分娩后不久恢复正常。血清维生素B6水平缓慢上升，产后6个月时仍有25%低于可接受范围。然而，反映维生素B6细胞内含量的谷草转氨酶刺激率在此时完全正常。血清叶酸是唯一的例外，45%的血清水平处于边缘或缺乏范围；该组中20%的人红细胞叶酸水平也处于缺乏或边缘范围。这表明孕期叶酸的“净消耗”相当大，叶酸储备的补充需要6个月以上的时间。
