Porter D A, Costill D L, Zachwieja J J, Krzeminski K, Fink W J, Wagner E, Folkers K
Wright State University, Department of Orthopedics, Dayton, OH 45509, USA.
Int J Sports Med. 1995 Oct;16(7):421-7. doi: 10.1055/s-2007-973031.
In order to determine the effect of oral Coenzyme Q10 (CoQ10) dosing on exercise capacity, 15 middle-aged men (44.7 +/- 2.0 years) received either CoQ10 (150 mg/day x 2 months-Q10 GRP) or placebo (2 months-CON GRP). Blood CoQ10 levels increased (p < 0.05) during the treatment in the Q10 GRP (Pre = 0.72 +/- 0.06, 2 months = 1.08 +/- 0.14 micrograms/ml) and were unchanged in the CON GRP (Pre = 0.91 +/- 0.05, 2 month = 0.69 +/- 0.05 microgram/ml). Similarly, the subjective perception of vigor (visual analog scale 1-10 where, 10 = very energetic, and 0 = very, very unenergetic) increased (p < 0.05) in the Q10 GRP (Pre = 5.73 +/- 0.35, 2 month = 6.64 +/- 0.45). However, maximal oxygen consumption (VO2max Pre = 2.97 +/- 0.18, 2 month = 3.05 +/- 0.15 l/min) and lactate threshold (LT Pre = 2.04 +/- 0.12, 2 month = 2.08 +/- 0.12 l/min), as measured on the cycle ergometer, were unchanged as a result of the CoQ10 treatment, Neither forearm oxygen uptake, nor forearm blood flow was found to be affected by the CoQ10. Although lactate release during hand-grip testing tended to decrease in the Q10 GRP (Pre = 227 +/- 49, 2 month = 168.3 +/- 40 mumole/min) this was not significant (p > 0.05). It can be concluded that short-term (2 months) oral dosing with CoQ10 increases circulating blood levels of CoQ10 and the subjective perceived level of vigor in middle-aged men. However, short-term dosing does not improve aerobic capacity or firearm exercise metabolism as measured in this investigation.
为了确定口服辅酶Q10（CoQ10）剂量对运动能力的影响，15名中年男性（44.7±2.0岁）接受了CoQ10（150毫克/天，共2个月-Q10组）或安慰剂（2个月-对照组）治疗。在治疗期间，Q10组的血液CoQ10水平升高（p<0.05）（治疗前=0.72±0.06，2个月后=1.08±0.14微克/毫升），而对照组则无变化（治疗前=0.91±0.05，2个月后=0.69±0.05微克/毫升）。同样，Q10组的活力主观感受（视觉模拟量表1-10，其中10=非常精力充沛，0=非常非常没精力）有所增加（p<0.05）（治疗前=5.73±0.35，2个月后=6.64±0.45）。然而，通过自行车测力计测量的最大耗氧量（VO2max治疗前=2.97±0.18，2个月后=3.05±0.15升/分钟）和乳酸阈值（LT治疗前=2.04±0.12，2个月后=2.08±0.12升/分钟），并未因CoQ10治疗而发生变化。CoQ10对前臂摄氧量和前臂血流量均无影响。尽管在Q10组中，握力测试期间的乳酸释放量有下降趋势（治疗前=227±49，2个月后=168.3±40微摩尔/分钟），但差异不显著（p>0.05）。可以得出结论，中年男性短期（2个月）口服CoQ10可提高循环血液中的CoQ10水平以及活力的主观感受水平。然而，在本研究中，短期给药并不能改善有氧能力或上肢运动代谢。
